Summer 2001
  Rules of Evidence

Jet Lag May Harm Memory

Putting Gingko to the Test

Depression and Memory

Patient Profile

Memory Tip
 
 
  Galantamine

Galantamine is a drug used for treatment of the symptoms associated with Alzheimer's disease (AD). It was approved by the US Food and Drug Administration (FDA) in 2001 and is currently marketed in the US (under the trade name Reminyl) by Janssen Pharmaceutica and Ortho-McNeil. Galantamine is extracted from daffodil bulbs.

Galantamine works to increase the level of acetylcholine in the brain. Acetylcholine is a neurotransmitter which is important for learning and memory; one feature of AD is a reduction in brain levels of acetylcholine. Like the other currently-available AD drugs, tacrine (trade name Cognex), donepezil (trade name Aricept), and rivastigmine (trade name Exelon), galantamine is a cholinesterase inhibitor, meaning that it acts to inhibit the enzymes which break down unused acetylcholine; the result is that existing acetylcholine survives longer and is more effective. Additionally, galantamine may work to stimulate the release of new acetylcholine in the brain.

   
 
 
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